This study was on the knowledge and acceptance on men towards vasectomy as a method of contraceptive among male staff at central hospital, Agbor150 questionnaires were administered and 120 were retrieved successfully and analysed. Closed ended structured questionnaires were used to collect information from the researcher to knowledge and acceptance on men towards vasectomy as a method of contraceptive. The data analysed were incorporated in frequency tables with their percentages after which the tables were elucidated on. 70 (58.33%) said they have heard of vasectomy while 50 (41.67%) has never heard of vasectomy before, 15 (12.5%) said they have thought of choosing vasectomy as a method of contraceptive while 105 (87.5%) did not accept it, 105 (87.5%) said their religious believe was not in support of it while 15 (12.50%) did not see anything wrong with vasectomy. The hypothetical statements was tested using chi-square and a level of significance of 0.05 with a theoretical value of 55.07 which was higher than the computed value which made the null hypothesis to be accepted . The data analyzed were compared with the empirical works for similarities and dissimilarities and reasons for dissimilarities were discussed. It was recommended that the hospital administration should organize seminar and workshop on vasectomy to enhance the knowledge of men on the acceptance of vasectomy as a method of contraceptive also the government should create more awareness on vasectomy via Mass media (Radio, Television, Newspaper)..